反应详情

A mixture of 0.8 g (1.26 mmol) of trans-N-[5-[((2S)-3-{benzyl[4-(4-hydroxyphenyl)cyclohexyl]amino}-2-hydroxypropyl)oxy]-2-(benzyloxy)phenyl]methanesulfonamide and of 0.2 g of 10% palladium-on-charcoal (50% in water) in ethanol (40 ml) is placed under hydrogen atmosphere and stirred for 2 h. The reaction mixture is filtered through celite. The solvents are evaporated under reduced pressure and trans-N-{2-hydroxy-5-[((2S)-2-hydroxy-3-{[4-(4-hydroxyphenyl)cyclohexyl]amino}propyl)oxy]phenyl}methanesulfonamide is obtained in the form of a white solid (0.24 g, 67%) after purification on silica gel (eluent: dichloromethane/methanol, 95/5 to 80/20 gradient in 15 min).

1. filtrationThe reaction mixture is filtered through celite
2. customThe solvents are evaporated under reduced pressure