反应详情

A mixture of ethyl trans-(4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}phenoxy)acetate (0.26 mmol) and of 0.25 g of 10% palladium-on-charcoal (50% in water) in ethanol (16 ml) is placed under hydrogen atmosphere and stirred for 7 h. The reaction mixture is filtered through celite. The solvents are evaporated under reduced pressure and ethyl trans-(4-{4-[((2S)-2-hydroxy-3-{4-hydroxy-3-[(methylsulfonyl)amino]phenoxy}propyl)amino]cyclohexyl}-phenoxy)acetate is obtained in the form of a white solid (0.08 g, 54%) after purification on silica gel (eluent: dichloromethane/methanol, 99/1 to 85/15 gradient in 30 min).

1. filtrationThe reaction mixture is filtered through celite
2. customThe solvents are evaporated under reduced pressure