Sodium Hydroxide → HCID 178505059, compound

Participants

Reaction Steps

A mixture of 0.36 g of ethyl trans-(4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}phenoxy)acetate (0.49 mmol) and of 6 ml of a molar aqueous sodium hydroxide solution in ethanol (10 ml) is heated at 45° C. for 22 h. The solvents are subsequently evaporated under reduced pressure and water is added. A molar aqueous hydrochloric acid solution is subsequently added to pH=1. The title product is obtained in the form of a white solid (0.3 g, 89%) after filtration and drying under vacuum. {M+H+]=689.7

Provenance & Evidence