HCID 178472569, compound → HCID 178472570, compound

Participants

Reaction Steps

A suspension of 1.35 g (0.35 mmol) of ethyl trans-(2S)-2-[(4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}benzoyl)amino]-3-methylbutanoate and of 0.177 g of palladium-on-charcoal (10% Pd, 50% in water) in 15 ml of ethanol is placed under hydrogen atmosphere and stirred for 3 h. The catalyst is subsequently filtered off and the solvents are evaporated under reduced pressure. The title compound is obtained in the form of a white solid (0.138 g, 44%) after purification on silica gel (eluent: dichloromethane/methanol/aqueous ammonia 99/1/0.1 to 85/15/1.5 gradient in 30 min).

Provenance & Evidence