Sodium Hydroxide → HCID 178505056, compound

Participants

Reaction Steps

A mixture of 0.35 g of ethyl trans-N-(4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)-amino]cyclohexyl}benzoyl)-L-phenylalaninate (0.42 mmol) and of 1.7 ml of a molar aqueous sodium hydroxide solution in ethanol (9.3 ml) is heated at 45° C. for 3 h. The solvents are subsequently evaporated under reduced pressure and water is added. A molar aqueous hydrochloric acid solution is subsequently added to pH=1. The title product is obtained in the form of a white solid (0.2 g, 59%) after filtration and drying under vacuum [M+H+]=807.

Provenance & Evidence