HCID 178504821, compound → HCID 178504824, compound

Participants

Reaction Steps

A mixture or 0.166 g of trans-4-[4-(benzyl{(2S)-3-[4-(benzyloxy)-3-(methylsulfonyl)phenoxy]-2-hydroxypropyl}amino)cyclohexyl]-N′-phenylbenzohydrazide (0.226 mmol) and of 0.1 g of 10% palladium-on-charcoal (50% in water) in a mixture of ethanol (3.9 ml) and tetrahydrofuran (2.93 ml) is placed under hydrogen atmosphere and stirred for 48 h. The catalyst is subsequently filtered off and the solvents are evaporated under reduced pressure. The title compound is obtained in the form of a white solid (0.02 g, 16%) after purification on silica gel (eluent: dichloromethane/methanol/aqueous ammonia 99/1/0.1 to 85/15/1.5 gradient in 30 min).

Provenance & Evidence