HCID 178504820, compound → HCID 178504823, compound

Participants

Reaction Steps

A mixture of 0.166 g of trans-4-[4-(benzyl{(2S)-3-[4-(benzyloxy)-3-(methylsulfonyl)phenoxy]-2-hydroxypropyl}amino)cyclohexyl]-N-(4-fluorobenzyl)benzamide (0.226 mmol) and of 0.117 g of 10% palladium-on-charcoal (50% in water) in a mixture of ethanol (5.3 ml) and tetrahydrofuran (4.02 ml) is placed under a hydrogen atmosphere and stirred for 48 hours. The catalyst is subsequently filtered off and the solvents are evaporated under reduced pressure. The title compound is obtained in the form of a white solid (0.92 g, 52%) after purification on silica gel (eluent: dichloromethane/methanol/aqueous ammonia 99/1/0.1 to 85/15/1.5 gradient in 30 min).

Provenance & Evidence