HCID 178471701, compound → HCID 178471699, compound

Participants

Reaction Steps

A mixture of 1.9 g of ethyl trans-2-{4-[4-(benzylamino)cyclohexyl]phenoxy}-2,2-dimethylacetate in the base form (4.8 mmol) and of 0.1 g of 10% palladium-on-charcoal in ethanol (75 ml) is placed under hydrogen atmosphere at 40° C. and stirred for 7 h. The reaction mixture is filtered through celite. The solvent is evaporated under reduced pressure and ethyl trans-2-[4-(4-aminocyclohexyl)phenoxy]-2,2-dimethylacetate is obtained (0.660 g) in the form of a yellow oil which is dissolved in ethanol (5 ml). The solution is acidified with a solution (9N) of HCl in ethanol and the solid thus obtained is filtered off (0.530 g, 72%). Melting point: 240-242.

Provenance & Evidence