N-(4-hydroxy-2,3,6-trimethylphenyl)formamide → HCID 73856748, compound

HRID 272314Notes

Reaction equation

HRID 272314 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([NH:9][CH:10]=[O:11])=[C:4]([CH3:12])[C:3]=1[CH3:13].Br[CH2:15][C:16]([CH3:25])=[CH:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1>C(OCC)(=O)C.CCCCCC>[F:24][C:21]1[CH:22]=[CH:23][C:18]([CH:17]=[C:16]([CH3:25])[CH2:15][O:1][C:2]2[CH:7]=[C:6]([CH3:8])[C:5]([NH:9][CH:10]=[O:11])=[C:4]([CH3:12])[C:3]=2[CH3:13])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 21961295N-(4-hydroxy-2,3,6-trimethylphenyl)formamideHCID 68705934HCID 68705934, compound

Product 1

HCID 73856748HCID 73856748, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using N-(4-hydroxy-2,3,6-trimethylphenyl)formamide and 1-(3-bromo-2-methyl-1-propenyl)-4-fluorobenzene, the title compound was synthesized according to Reference Example 17a. Yield: 52%. Melting point: 164-165° C. (Ethyl acetate-hexane)

Sources & evidence

ORD record
ord-b8aa9ce726ec49f88c30aa5ab07d4832
Source dataset
uspto-grants-2008_11
Patent number
US07456162B2

Reaction notes

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