Butanal → HCID 70588461, compound

HRID 27235Notes

Reaction equation

HRID 27235 reaction equation
[CH:1](=O)[CH2:2][CH2:3][CH3:4].[CH:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.S([O-])([O-])(=O)=O.[Na+].[Na+]>>[CH:1](=[C:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[NH2:12])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 261Butanal2×HCID 7965Cyclohexylamine2×HCID 24436Sodium Sulfate

Product 1

HCID 70588461HCID 70588461, compoundYield 86%

Procedure

At 0° C., 16.3 g (20 mL, 0.23 mol) of butyraldehyde (Formula IV) was added dropwise to 21.7 g (25 mL, 0.22 mol) of cyclohexylamine (Formula III). After 1 h, 6 g of anhydrous sodium sulfate was added and the mixture stirred for 5 h. The product was decanted from the salt water slurry, dried by addition of further 10 g of anhydrous sodium sulfate, filtered and distilled. Characteristics of the product: bp 88° C. (20 mm); yield 86%; NMR (CDCl3, δ): 1.0 (3H, t) 1.1-2.1 (12H), 2.3 (2H, g), 3.0 (1H, m), 7.8 (1H, t).

Workup

  1. customThe product was decanted from the salt water slurry
  2. dry with materialdried by addition of further 10 g of anhydrous sodium sulfate
  3. filtrationfiltered
  4. distillationdistilled

Sources & evidence

ORD record
ord-5176bc7b717446ac88b809a2854aef31
Source dataset
uspto-grants-1980_09
Patent number
US04220774

Reaction notes

Loading…