53041-12-6 → HCID 21961349, compound

HRID 272353Notes

Reaction equation

HRID 272353 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([NH:9][CH:10]=[O:11])=[C:4]([CH3:12])[C:3]=1[CH3:13].Br[CH2:15]/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1>C(OCC)(=O)C.CCCCCC>[F:24][C:21]1[CH:22]=[CH:23][C:18](/[CH:17]=[CH:16]/[CH2:15][O:1][C:2]2[CH:7]=[C:6]([CH3:8])[C:5]([NH:9][CH:10]=[O:11])=[C:4]([CH3:12])[C:3]=2[CH3:13])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 1183083153041-12-6HCID 21961295N-(4-hydroxy-2,3,6-trimethylphenyl)formamide

Product 1

HCID 21961349HCID 21961349, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using N-(4-hydroxy-2,3,6-trimethylphenyl)formamide and 1-[(E)-3-bromo-1-propenyl]-4-fluorobenzene, the title compound was synthesized according to Reference Example 17b. Yield: 52%. Melting point: 196-198° C. (Ethyl acetate-hexane)

Sources & evidence

ORD record
ord-354d5d6c382f45adbb1a05a5eca38b1e
Source dataset
uspto-grants-2008_11
Patent number
US07456162B2

Reaction notes

Loading…