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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 272365Generated: October 30, 2026

4-Fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamide → N-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-amine

https://huagongshe.com/reaction/272365

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamideHCID 10294590—
SolventMethanolHCID 887—
ProductN-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-amineHCID 988667060%

Reaction Steps

By using 4-fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamide, the title compound was synthesized according to Example 2b. Yield: 60%. Melting point: 93-95° C. (Methanol)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07456162B2
Source datasetuspto-grants-2008_11
ORD IDord-ec4acf573d8d4816826c481f8c784896
Source noteuspto-grants-2008_11