1,3-Benzodioxole-5-carbonyl chloride → HCID 10183771, compound

HRID 272379Notes

Reaction equation

HRID 272379 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:22])=[C:16]([NH2:21])[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:24])[CH3:23])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[O:25]1[C:29]2[CH:30]=[CH:31][C:32]([C:34](Cl)=[O:35])=[CH:33][C:28]=2[O:27][CH2:26]1>C(OCC)C.CCCCCC>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:22])=[C:16]([NH:21][C:34]([C:32]4[CH:31]=[CH:30][C:29]5[O:25][CH2:26][O:27][C:28]=5[CH:33]=4)=[O:35])[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:24])[CH3:23])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 105199783-(4-Isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine

Product 1

HCID 10183771HCID 10183771, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

By using 3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine and 1,3-benzodioxol-5-carbonyl chloride, the title compound was synthesized according to Example 1b. Yield: 67%. Melting point: 165-167° C. (Ethyl ether-hexane)

Sources & evidence

ORD record
ord-2e3ac3ca294e44e6b67731b3c3d90cb8
Source dataset
uspto-grants-2008_11
Patent number
US07456162B2

Reaction notes

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