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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 272390Generated: October 25, 2026

4-Fluoro-N-(2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]benzamide → N-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-amine

https://huagongshe.com/reaction/272390

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-N-(2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]benzamideHCID 10202094—
SolventMethanolHCID 887—
ProductN-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-amineHCID 993102439%

Reaction Steps

By using 4-fluoro-N-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]benzamide, the title compound was synthesized according to Example 2b. Yield: 39%. Melting point: 92-94° C. (Methanol)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07456162B2
Source datasetuspto-grants-2008_11
ORD IDord-ada468b769ef428189e01784e43f5d12
Source noteuspto-grants-2008_11