4-Fluorobenzoyl chloride → HCID 10135914, compound

HRID 272403Notes

Reaction equation

HRID 272403 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[C:13]([CH3:20])=[C:14]([NH2:19])[C:15]([CH3:18])=[C:16]([CH3:17])[C:11]=3[O:10][C:9]=2[CH3:21])=[CH:4][CH:3]=1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1>C(OCC)(=O)C.CCCCCC>[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH:19][C:14]2[C:15]([CH3:18])=[C:16]([CH3:17])[C:11]3[O:10][C:9]([CH3:21])=[C:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[C:12]=3[C:13]=2[CH3:20])=[O:28])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 68886630HCID 68886630, compound

Product 1

HCID 10135914HCID 10135914, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using 3-(4-fluorophenyl)-2,4,6,7-tetramethyl-1-benzofuran-5-amine and 4-fluorobenzoyl chloride, the title compound was synthesized according to Example 1b. Yield: 75%. Melting point: 232-234° C. (Ethyl acetate-hexane).

Sources & evidence

ORD record
ord-b1e28c467d5f4ecf88ab24a80b3e4dfe
Source dataset
uspto-grants-2008_11
Patent number
US07456162B2

Reaction notes

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