HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → diphenylmethyl (2R)-2-[(1R,5S)-3-phenyl-7-oxo-4-oxa-2,6-diazabicyclo[3,2,0]hept-2-en-6-yl]-3-chloromethyl-3-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 12911969 | HCID 12911969 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | diphenylmethyl (2R)-2-[(1R,5S)-3-phenyl-7-oxo-4-oxa-2,6-diazabicyclo[3,2,0]hept-2-en-6-yl]-3-chloromethyl-3-butenoate | HCID 56996092 | — |
Reaction Steps
A solution of 100 mg of Compound (1a) in 3 ml of methylene chloride is mixed with 0.2 ml of a 1.66 N solution of chlorine in carbon tetrachloride at 38° C. with stirring under nitrogen atmosphere to yield Compound (7) after silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04220766 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-5171c4ce16e741f8a4f5e089cf8bb0d1 |
| Source note | uspto-grants-1980_09 |