HRID272524

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21241

1-Butene, 4-bromo-

C4H7Br

HCID160419

Succinate

C4H4O4-2

HCID2729681

未命名化合物

结构：C=CC[C@H](C(=O)NCc1cc(F)cc(F)c1)[C@@H](CC(C)C)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O

HCID9916426

未命名化合物

PRODUCTS

生成物

结构：C=CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O

HCID9912782

未命名化合物

PROCEDURE

实验过程

A procedure analogous to the preparation of Example 5 was followed. The appropriate succinate ester was prepared using the method disclosed in PCT publication WO 98/51665), using 3-butenyl bromide for R3—X in place allyl bromide (see Scheme 2). The anti-succinate half-ester was coupled to (S)-isomer benzodiazepine (30) using the procedures of Step 1. After Steps 2 and 3, the title compound was isolated. MS (M+H)+=475.3; (M+Na)+=497.3.

WORKUP

后处理

customA procedure analogous to the preparation of Example 5

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3fc39e7433a24db287670b7b6d2de22a
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07456172B2
来源说明: uspto-grants-2008_11

反应 SMILES

[CH2:1](Br)[CH2:2][CH:3]=C.[CH3:6][N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:10][CH:9]([NH:24][C:25](=[O:47])[C@H:26]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:27]([CH2:40]C=C)[C:28]([NH:30]CC2C=C(F)C=C(F)C=2)=[O:29])[C:8]1=[O:48].C([O-])(=O)CCC([O-])=O.CN1C2C=CC=CC=2C(C2C=CC=CC=2)=NC(N)C1=O>>[CH3:6][N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:10][C@H:9]([NH:24][C:25](=[O:47])[C@H:26]([CH2:43][CH:44]([CH3:45])[CH3:46])[C@H:27]([CH2:40][CH2:3][CH:2]=[CH2:1])[C:28]([NH2:30])=[O:29])[C:8]1=[O:48]