Ethyl-4-(4-nitro-pyridin-2-yl)-piperazine → 2-(4-Ethylpiperazin-1-yl)pyridin-4-amine

HRID 272527Notes

Reaction equation

HRID 272527 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][N:10]=2)[CH2:5][CH2:4]1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[C:13]([NH2:15])[CH:12]=[CH:11][N:10]=2)[CH2:7][CH2:8]1)[CH3:2]

Participants

5

Reactant 2

HCID 68942070Ethyl-4-(4-nitro-pyridin-2-yl)-piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 617095722-(4-Ethylpiperazin-1-yl)pyridin-4-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2.03 g (9 mmol) 1-ethyl-4-(4-nitro-pyridin-2-yl)-piperazine in 30 ml methanol was hydrogenated over 0.052 g Pd/C with 1 bar hydrogen for 3 h at room temperature. The mixture was filtered and evaporated to dryness to yield the title compound as yellow solid which was used without further purification (m/e): 207.1 (MH+; 100%).

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-d47d9ff1311f4cc2b36faa43d77f393b
Source dataset
uspto-grants-2008_11
Patent number
US07456175B2

Reaction notes

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