1-Cyclopentylpiperazine → N-[2-(4-Cyclopentyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	1-Cyclopentylpiperazine	HCID 806421	—
Reactant	N-(2-Chloro-4-pyridinyl)-N-methylacetamide	HCID 45119279	—
Product	N-[2-(4-Cyclopentyl-piperazin-1-yl)-pyridin-4-yl]-N-methyl-acetamide	HCID 68942069	—

Reaction Conditions

Temperature	120 °C

Reaction Steps

A mixture of 4 g (22 mmol) N-(2-chloro-pyridin-4-yl)-N-methyl-acetamide and 3.5 g (23 mmol) 1-(cyclopentyl)-piperazine was heated to 120° C. for 24 h. The crude product was purified by flash column chromatography on silica eluting with a gradient formed from heptane and ethyl acetate (0.1% NEt3) to yield after evaporation of the product fractions 3.3 g (50%) of the title compound as light brow oil. MS: (m/e): 303.3 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07456175B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-a4c17bb9cba04695b1cd7ef560ba1877
Source note	uspto-grants-2008_11