Potassium Hydroxide → 3-Benzyl-3-azabicyclo[3.2.1]octan-6-ol

Participants

Reaction Steps

To a solution of acetic acid 3-benzyl-3-aza-bicyclo[3.2.1]oct-6-yl ester (8 mmol) in methanol (50 mL) and water (20 mL) was added potassium hydroxide (32 mmol). Reaction was stirred 18 h at room temperature. The methanol was removed in vacuo and product was extracted with aqueous dichloromethane (4×50 mL). The organic extracts were dried over MgSO4, filtered and stripped to provide a quantitative yield of an oil. APCl MS m/z 218.2 (M+H)+.

Provenance & Evidence