HRID272653

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733661

D-3-(2-Naphthyl)alanine

C13H13NO2

结构：C[C@@H]1CN(C(=O)[C@H](N)Cc2ccc3ccccc3c2)[C@@H](CCCNC(=N)N)CN1C(=O)Cc1ccc2ccccc2c1

HCID178461576

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N1C[C@@H](C)N(C(=O)Cc2ccc3ccccc3c2)C[C@@H]1CCCNC(=N)N

HCID178475061

未命名化合物

PROCEDURE

实验过程

The following compound was synthesized by the method of Scheme 6. The compound of Example 38 was treated by the method of Example 36 to introduce an acetyl group at the amino group of the D-2-Nal residue. It was tested as described above with the results shown. The mass was analyzed as 607.7 (M+H).

WORKUP

后处理

customThe following compound was synthesized by the method of Scheme 6

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b35af4103a02471c9772ee65d86092c9
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07456184B2
来源说明: uspto-grants-2008_11

反应 SMILES

[NH2:1][C@H:2]([CH2:32][C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=1)[C:3]([N:5]1[CH2:10][C@@H:9]([CH3:11])[N:8]([C:12](=[O:24])[CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[CH2:7][C@@H:6]1[CH2:25][CH2:26][CH2:27][NH:28][C:29]([NH2:31])=[NH:30])=[O:4].N[C@@H:44]([C:56](O)=[O:57])CC1C=C2C(C=CC=C2)=CC=1>>[NH:28]([CH2:27][CH2:26][CH2:25][C@H:6]1[CH2:7][N:8]([C:12](=[O:24])[CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[C@H:9]([CH3:11])[CH2:10][N:5]1[C:3](=[O:4])[C@H:2]([NH:1][C:56](=[O:57])[CH3:44])[CH2:32][C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=1)[C:29]([NH2:31])=[NH:30]