Sulfuryl chloride → Ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-propargyloxyimino-3-oxobutyrate (syn isomer, 71.2 g), acetic acid (81 ml) and sulfuryl chloride (50.2 g) was stirred at 40° C. for 10 minutes and then at room temperature for 5.5 hrs. The reaction mixture was treated in a conventional manner to give ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate (syn isomer, 61.6 g.), oil.

Provenance & Evidence