HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 27267Generated: October 25, 2026
Water → Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate
https://huagongshe.com/reaction/27267
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate | HCID 53939675 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate | HCID 53907014 | 53.5% |
Reaction Steps
A mixture of ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate (syn isomer, 61 g), thiourea (20 g), sodium acetate 3-hydrate (35.8 g), water (150 ml), and ethanol (180 ml) was stirred at 40° C. for 1.25 hrs. The reaction mixture was treated in a conventional manner to give ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate (syn isomer, 35.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04220761 |
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| Source dataset | uspto-grants-1980_09 |
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| ORD ID | ord-46fc5252a5cc4532a5ffd2671473a123 |
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| Source note | uspto-grants-1980_09 |
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