Acetic Anhydride → Methyl 2-(3-Acetamidophenyl)acetate

HRID 272696Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[CH3:12][O:11][C:9](=[O:10])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:13](=[O:15])[CH3:14])[CH:3]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 13054266Methyl 3-aminophenylacetate

Product 1

HCID 86595380Methyl 2-(3-Acetamidophenyl)acetate

Procedure

Methyl (3-aminophenyl)acetate was treated with acetic anhydride to provide methyl[3-(acetylamino)phenyl]acetate. The desired product was prepared by substituting methyl[3-(acetylamino)phenyl]acetate for N-[4-(cyanomethyl)phenyl]acetamide in Example 6A. MS (DCI) m/e 211 (M+H)+.

Sources & evidence

ORD record: ord-58642224535c432398666c13eb36ab96
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07456169B2

Reaction notes

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