HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(4-Aminopyridin-3-YL)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl N-[3-(2-hydroxyethyl)pyridin-4-yl]carbamate | HCID 11031933 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Aminopyridin-3-YL)ethanol | HCID 45079443 | 40% |
Reaction Steps
A solution of [3-(2-hydroxy-ethyl)-pyridin-4-yl]-carbamic acid tert-butyl ester (91 mg, 0.38 mmol) in CH2Cl2 (3 mL) was treated with TFA (2 mL) and stirred at room temperature for 3 hours. Concentrated under vacuum to provide 21 mg (23%) of desired product. MS (DCI) m/e 139 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456169B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-36b084094e9d4f2f8d190046e6a6dcfb |
| Source note | uspto-grants-2008_11 |