HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 27271Generated: October 25, 2026
Water → Ethyl 2-(2-aminothiazol-4-yl)-2-(2-benzoyloxyethoxyimino)acetate
https://huagongshe.com/reaction/27271
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 2-(2-benzoyloxyethoxyimino)-4-chloro-3-oxobutyrate | HCID 53906646 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-aminothiazol-4-yl)-2-(2-benzoyloxyethoxyimino)acetate | HCID 53954764 | 29.2% |
Reaction Steps
A mixture of ethyl 2-(2-benzoyloxyethoxyimino)-4-chloro-3-oxobutyrate (syn isomer, 29 g.), thiourea (7.76 g.), sodium acetate (8.37 g.), water (75 ml.) and ethanol was stirred at 40° C. for an hour. The reaction mixture was treated in a conventional manner to give ethyl 2-(2-aminothiazol-4-yl)-2-(2-benzoyloxyethoxyimino)acetate (syn isomer, 9 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04220761 |
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| Source dataset | uspto-grants-1980_09 |
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| ORD ID | ord-c7c9b4c983774cf492da51e178dce036 |
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| Source note | uspto-grants-1980_09 |
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