HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 272748Generated: October 31, 2026
Morpholine → 4-(4-Chloro-2-methoxybenzyl)morpholine
https://huagongshe.com/reaction/272748
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-(Bromomethyl)-4-chloro-2-methoxybenzene | HCID 22327474 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(4-Chloro-2-methoxybenzyl)morpholine | HCID 69217536 | 93.3% |
Reaction Steps
A mixture of 1-bromomethyl-4-chloro-2-methoxy-benzene (705 mg), morpholine (0.52 mL, 6 mmol) in toluene (15 mL) was heated to 110° C. for 2 hours. The solution was then partitioned between ethyl acetate and water. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated under vacuum to provide 675 mg (93%) of the title compound. MS (ESI) m/e 242 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07456169B2 |
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| Source dataset | uspto-grants-2008_11 |
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| ORD ID | ord-58123c9ce2ea42b7a57eccc0d614b280 |
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| Source note | uspto-grants-2008_11 |
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