HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 1-(3-Chloro-propyl)-2-methyl-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | 2-Methylpyrrolidine | HCID 13003 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(3-Chloro-propyl)-2-methyl-pyrrolidine | HCID 12573267 | 59% |
Reaction Steps
2-Methylpyrrolidine (0.9 g, 10.6 mmol), acetone (18 ml, 20 vol), 5M NaOH solution (2.50 ml) and 1-bromo-3-chloropropane (5 g, 31.8 mmol, 3 eq) were reacted together according to general procedure A to give the title compound (1 g, 59%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-0a349c2eadc3405ab1aba21bd02136f8 |
| Source note | uspto-grants-2008_11 |