HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 2-[1-(3-Chloropropyl)piperidin-4-yl]ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Piperidineethanol | HCID 73953 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-[1-(3-Chloropropyl)piperidin-4-yl]ethan-1-ol | HCID 40424327 | 38.9% |
Reaction Steps
4-Piperidine ethanol (0.9 g, 7.5 mmol), acetone (18 ml, 20 vol), 5M NaOH solution (1.8 ml) and 1-bromo-3-chloropropane (3.54 g, 22.5 mmol, 3 eq.) were reacted together according to general procedure A to give the title compound (0.6 g, 37%) as an orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-f30698aad9a04b93bb42b5650c55795a |
| Source note | uspto-grants-2008_11 |