Potassium Carbonate → HCID 59837397, compound

Participants

Reaction Steps

4-(4-Dimethylaminomethyl-tetrahydro-pyran-4-yl)-phenol (288 mg, 1.22 mmol), 2-[1-(3-chloro-propyl)-piperidin-4-yl]-ethanol (252 mg, 1.22 mmol), DMF (8 ml) and K2CO3 (674 mg, 4.88 mmol) were reacted together according to general procedure B. Purification by chromatography on silica, eluant DCM:MeOH:NH3 (96:4:1) provided the title compound (180 mg, 36%) as an off white solid. 1H NMR (400 MHz, CDCl3) δ7.20 (d, 2H), 6.86 (d, 2H), 3.99 (t, 2H), 3.75 (dt, 2H), 3.70 (t, 2H), 3.55 (td, 2H), 2.98-2.88 (m, 2H), 2.49 (t, 2H), 2.40 (s, 2H), 2.14-1.82 (m, 6H), 1.97 (s, 6H), 1.75-1.15 (m, 10H).

Provenance & Evidence