HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → (3-Chloropropyl)(methyl)(propan-2-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-Methylisopropylamine | HCID 78485 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (3-Chloropropyl)(methyl)(propan-2-yl)amine | HCID 23091614 | 66% |
Reaction Steps
Isopropylmethylamine (4 g, 56 mmol), acetone (12 ml, 3 vol), 5M NaOH solution (13.44 ml, 1.2 eq.) and 1-bromo-3-chloropropane (13.22 g, 84 mmol, 1.5 eq.) were reacted together according to general procedure A to give the title compound (4.8 g, 66%) as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5cef553629dc481c8d1b26f96aca15bb |
| Source note | uspto-grants-2008_11 |