反应详情

To the solution of 4.4 g of 9-ethylenedioxy-15-keto-19-methyl-prost-13,18-dienoic acid, methyl ester, in ethanol (60 ml.) are added 0.8 g of Raney-nickel washed with ethanol and the mixture is hydrogenated at room temperature under pressure. After absorption of the theoretical quantity of hydrogen the catalyzer is separated by filtration and the solvent evaporated in vacuo, to yield 3.9 g of 9-ethylenedioxy-15-keto-19-methyl-prost-18-enoic acid, methyl ester.

1. washwashed with ethanol
2. customis hydrogenated at room temperature under pressure
3. customAfter absorption of the theoretical quantity of hydrogen the catalyzer
4. customis separated by filtration
5. customthe solvent evaporated in vacuo