Potassium Carbonate → HCID 59837456, compound

Participants

Reaction Steps

4-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile (185 mg, 0.91 mmol), 2-[1-(3-chloro-propyl)-piperidin-4-yl]-ethanol (300 mg, 1.46 mmol), DMF (4 ml) and K2CO3 (497 mg, 3.60 mmol) were reacted together according to general procedure E. Purification by chromatography on silica, eluant DCM:MeOH:NH3 (92:6:2) provided the title compound (220 mg, 65%) as a pale pink solid. 1H NMR (400 MHz, CDCl3) δ 7.37 (d, 2H), 6.93 (d, 2H), 4.11-4.04 (m, 2H), 4.01 (t, 2H), 3.89 (td, 2H), 3.70 (t, 2H), 2.97-2.87 (m, 2H), 2.48 (t, 2H), 2.15-1.88 (m, 8H), 1.77-1.57 (m, 3H), 1.57-1.38 (m, 3H), 1.35-1.21 (m, 2H).

Provenance & Evidence