Trifluoroacetic acid → HCID 68576434, compound

Participants

Reaction Steps

tert-Butyl 4-[4-(4-cyanotetrahydro-2H-pyran-4-yl)phenoxy]-1-piperidinecarboxylate (720 mg) was dissolved in dichloromethane (50 ml) at 0° C. TFA (10 ml) was added and the mixture stirred whilst warming to room temperature over 2 hours. The reaction mixture was then concentrated in vacuo, and partitioned between dichloromethane (80 ml) and 0.5M NaOH (50 ml). The dichlorormethane solution was dried over Na2SO4 and evaporated to give 4-[4-(4-piperidinyloxy)phenyl]tetrahydro-2H-pyran-4-carbonitrile as a colorless oil which crystallized on standing (500 mg, 94%).

Provenance & Evidence