1-Methylpiperazine → HCID 59837454, compound

HRID 272965Notes

Reaction equation

[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3([C:23]([OH:25])=O)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3([C:23]([N:30]4[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]4)=[O:25])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:16]=2)[CH2:6][CH2:5]1)([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 598374534-{4-[(1-Isopropylpiperidin-4-yl)oxy]phenyl}tetrahydro-2H-pyran-4-carboxylic acid

Product 1

HCID 59837454HCID 59837454, compoundYield 48%

Procedure

The title compound (60 mg, 48%) was prepared from 4-{4-[(1-isopropylpiperidin-4-yl)oxy]phenyl}tetrahydro-2H-pyran-4-carboxylic acid and N-methyl piperazine similarly to the procedure used for example 150. 1H NMR (400 MHz, CDCl3) δ 1.05 (d, 6H), 1.79-1.81 (m, 2H), 2.00-2.03 (m, 7H), 2.15 (s, 3H), 2.18-2.22 (m, 2H), 2.37-2.42 (m, 2H), 2.77-2.79 (m, 3H), 2.99 (m, 1H), 3.27-3.56 (m, 4H), 3.78 (t, 2H), 3.87-3.89 (m, 2H), 4.28 (m, 1H), 6.88 (d, 2H), 7.14 (d, 2H).

Sources & evidence

ORD record: ord-ff2d7add76d746959b7cbf2faa12e23d
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07456164B2

Reaction notes

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