1-Methylpiperazine

3.0 [mmHg]

Clear light yellow hygroscopic liquid; [Sigma-Aldrich MSDS]

839；847；852；838.5

1266；1270；1274；1282；1282；1286；1262

This chemical does not meet GHS hazard criteria for 1.1% (4 of 377) of reports.

Danger

H226 (98.7%): Flammable liquid and vapor [Warning Flammable liquids]；H312 (44.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H314 (98.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H317 (53.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H318 (51.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H330 (24.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]；H331 (12.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H332 (56.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 377 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 4 of 377 reports by companies.；There are 23 notifications provided by 373 of 377 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Piperazine, 1-methyl-

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739；Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18323

1-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Causes skin corrosion in acute dermal studies of rabbits; Causes convulsions in acute inhalation studies of mice; Causes multiple liver effects, changes in renal tubules, changes in recording from peripheral motor nerve, and general anesthesia in acute oral studies of mice; [RTECS] Causes burns; May cause skin sensitization; Harmful by inhalation; [ECHA REACH Registrations] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by skin absorption; Toxic by inhalation; [Sigma-Aldrich MSDS] See Piperazine and salts.

Flam. Liq. 3 (98.7%)；Acute Tox. 4 (44.8%)；Skin Corr. 1B (98.9%)；Skin Sens. 1B (53.8%)；Eye Dam. 1 (51.7%)；Acute Tox. 1 (24.4%)；Acute Tox. 3 (12.5%)；Acute Tox. 4 (56.8%)

Corrosives, Flammable agents - 2nd degree

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；Dermatotoxin - Skin burns.；Skin Sensitizer - An agent that can induce an allergic reaction in the skin.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (mouse) = 2,740 mg/m3/2hr

Chemical: Piperazine, 1-methyl-

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739；Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18323

1-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Used to make large scale and fine chemicals; [ECHA REACH Registrations]

Piperazine, 1-methyl-: ACTIVE