HCID 11667281, compound → HCID 86601904, compound

HRID 272971Notes

Reaction equation

HRID 272971 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4([C:24]#[N:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.P([O-])(OCC)(SCC)=[S:27]>>[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4([C:24](=[S:27])[NH2:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11667281HCID 11667281, compoundHCID 53249491Diethyldithiophosphate

Product 1

HCID 86601904HCID 86601904, compoundYield 50%

Procedure

The title compound (223 mg, 50%) was prepared from 4-{4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl}tetrahydro-2H-pyran-4-carbonitrile and diethyl dithiophosphate similarly to the procedure used for intermediate 50. LRMS APCI+ m/z 375 [MH]+.

Sources & evidence

ORD record
ord-039c67193b0e4eb4831f2a24fa521748
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

Loading…