Chloroacetone → HCID 59837513, compound

Participants

Reaction Steps

The title compound (155 mg, 83%) was prepared from 4-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}tetrahydro-2H-pyran-4-carbothioamide and chloroacetone similarly to the procedure used for example 136. 1H NMR (400 MHz, CDCl3) δ 1.64-1.71 (m, 2H), 1.78-1.81 (m, 2H), 1.88-2.04 (m, 6H), 2.10-2.20 (m, 2H), 2.31-2.38 (m, 2H), 2.42 (s, 3H), 2.61-2.64 (m, 4H), 2.74 (m, 1H), 3.71 (t, 2H), 3.81-3.85 (m, 2H), 4.28 (m, 1H), 6.75 (s, 1H), 6.83 (d, 2H), 7.23 (d, 2H). HRMS ESI+ m/z 413.2257 [MH]+.

Provenance & Evidence