2-Bromopyridine → HCID 59837420, compound

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Reaction Steps

The title compound (25 mg, 31%) was prepared from 1-(4-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}tetrahydro-2H-pyran-4-yl)methanamine and 2-bromopyridine similarly to the procedure used for example 152. 1H NMR (400 MHz, CDCl3) δ 1.68-1.72 (m, 2H), 1.84-1.94 (m, 6H), 2.00-2.16 (m, 8H), 2.63-2.67 (m, 2H), 2.74 (m, 1H), 3.49 (d, 2H), 3.56-3.62 (m, 2H), 3.80-3.85 (m, 2H), 4.02 (m, 1H), 4.31 (m, 1H), 6.22 (d, 1H), 6.51 (t, 1H), 6.91 (d, 2H), 7.24 (d, 2H), 7.32 (t, 1H), 8.01 (d, 1H). HRMS ESI+ m/z 422.2792 [MH]+.

Provenance & Evidence