HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 4-[4-(methylthio)phenyl]tetrahydro-2H-pyran-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Bis(2-bromoethyl) ether | HCID 21521 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(4-(Methylthio)phenyl)acetonitrile | HCID 2760087 | — |
| Product | 4-[4-(methylthio)phenyl]tetrahydro-2H-pyran-4-carbonitrile | HCID 68576613 | 77% |
Reaction Steps
The title compound (5.5 g, 77%, solid after trituration in pentane) was prepared using 4-(methylthio)phenylacetonitrile, bis(2-bromoethyl)ether, sodium hydride and potassium iodide similarly to the procedure used for intermediate 56. Microanalysis: Found: C, 66.62; H, 6.46; N, 5.97%. C13H15NOS requires C, 66.92; H, 6.48; N, 6.00%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07456164B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-d5f7c07a194b453e8a04f9ba24e4bd52 |
| Source note | uspto-grants-2008_11 |