Methyl vinyl sulfone → HCID 59837356, compound

Participants

Reaction Steps

To a stirred solution of N-methyl-1-{4-[4-(3-morpholin-4-ylpropoxy)phenyl]tetrahydro-2H-pyran-4-yl}methanamine (230 mg, 0.66 mmol) in methanol (2 mL) was added methanesulfonyl-ethene (64 μL, 0.72 mmol) and the mixture stirred at room temperature for 18 hours. The mixture was concentrated in vacuo and triturated with diethyl ether to give the title compound as a white solid (274 mg, 91%). 1H NMR (400 MHz, CDCl3) δ 1.81 (m, 2H), 1.97 (m, 2H), 2.04 (s, 3H), 2.13 (m, 2H), 2.42-2.58 (m, 8H), 2.62 (t, 2H), 2.74 (s, 3H), 2.81 (t, 2H), 3.50 (m, 2H), 3.70-3.80 (m, 6H), 4.00 (t, 2H), 6.86 (d, 2H), 7.20 (d, 2H). HRMS ESI+ m/z 455.2570 [MH]+. Microanalysis: Found: C, 60.61; H, 8.47; N, 6.09%. C23H38N2O5S requires C, 60.76; H, 8.42; N, 6.16%.

Provenance & Evidence