Aluminium lithium hydride → 10-Hydroxy-2-decanone

A solution of 95.4 g (370 mmol) of ethyl 9-oxodecanoate ethylene ketal (prepared in Example 22A-1) in 120 ml of ether was added dropwise to a stirred mixture of 10.5 g (277 mmol) of lithium aluminum hydride and 500 ml of ether under argon. The mixture was stirred for 18 hr and then quenched by the dropwise addition of 18 ml of ethyl acetate. To this mixture there was then sequentially added in dropwise fashion, with stirring, 10.5 ml of water, 10.5 ml of 15% aqueous sodium hydroxide and 31.1 ml of water. The mixture was stirred for about 2 to 3 hr and the mixture was then filtered. The filter pad was rinsed several times with ether. The combined filtrates were evaporated in vacuo. The residue was dissolved in a mixture of 250 ml of 10% hydrochloric acid and 120 ml of methanol and left to stand at room temperature for about 4 hr. The solution was evaporated in vacuo. This residue was dissolved in ether and the resulting solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated in vacuo to yield 74.3 g of a yellow oil. The product had the following physical characteristics:

1. customquenched by the dropwise addition of 18 ml of ethyl acetate
2. additionTo this mixture there was then sequentially added in dropwise fashion
3. stirringwith stirring
4. stirringThe mixture was stirred for about 2 to 3 hr
5. filtrationthe mixture was then filtered
6. washThe filter pad was rinsed several times with ether
7. customThe combined filtrates were evaporated in vacuo
8. dissolutionThe residue was dissolved in a mixture of 250 ml of 10% hydrochloric acid and 120 ml of methanol
9. waitleft
10. waitto stand at room temperature for about 4 hr
11. customThe solution was evaporated in vacuo
12. dissolutionThis residue was dissolved in ether
13. washthe resulting solution was washed with saturated aqueous sodium chloride
14. dry with materialdried over anhydrous magnesium sulfate
15. customevaporated in vacuo

ORD record

ord-a314ae1ce6a242c79f37a1ba59855fc9

Source dataset

uspto-grants-1980_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04220795