Potassium Carbonate → HCID 59837526, compound

Participants

Reaction Conditions

Reaction Steps

C-{4-[4-(3-[1,4]Oxazepan-4-yl-propoxy)-phenyl]-tetrahydro-pyran-4-yl}-methylamine (150 mg, 0.43 mmol) and 1-Bromo-2-(2-bromo-ethoxy)-ethane (110 mg, 0.47 mmol) were dissolved in acetonitrile (10 ml) and K2CO3 (130 mg, 0.95 mmol) was added. The solution was heated at 60° C. for 18 hours before filtering the solution to remove to the solid K2CO3. The filtrate was concentrated in vacuo before purifying using column chromatography, eluting with a gradient of DCM:MeOH:NH3 (from 99:1:0.1 to 90:10:1) to afford the title compound as a colourless oil (75 mg, 42%). 1H NMR (400 MHz, CD3OD) δ 1.80-2.00 (m, 6H), 2.11-2.20 (m, 6H), 2.41 (s, 2H), 2.69-2.79 (m, 6H), 3.48 (m, 6H), 3.72-3.80 (m, 6H), 4.02 (t, 2H), 6.87 (d, 2H), 7.15 (d, 2H). HRMS ESI+ m/z 419.2896 [MH]+.

Provenance & Evidence