HCID 68576037, compound → HCID 59837523, compound

Participants

Reaction Steps

4-{4-[4-(3-[1,4]Oxazepan-4-yl-propoxy)-phenyl]-tetrahydro-pyran-4-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester (260 mg, 0.48 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4M, 5 ml) and was stirred at room temperature for 2 hours. The solvent was removed in vacuo and the residue dissolved in DCM (10 ml) and washed with saturated sodium bicarbonate solution (15 ml). The organic layer was dried over Na2SO4 and concentrated in vacuo before purifying the residue using column chromatography, eluting with a gradient of DCM:MeOH:NH3 (from 99:1:0.1 to 92:8:0.8) to afford the title compound as a white solid (80 mg, 37%). 1H NMR (400 MHz, d6-DMSO) δ 1.70-1.88 (m, 6H), 2.08 (m, 2H), 2.52-2.63 (m, 6H), 3.04-3.35 (m, 8H), 3.58 (m, 4H), 3.64 (m, 2H), 3.72 (m, 2H), 3.98 (t, 2H), 6.92 (d, 2H), 7.12 (d, 2H). LRMS ESI+ m/z 432 [MH]+.

Provenance & Evidence