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HRID273266

反应详情

EQUATION

反应方程式

HRID 273266 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1c(F)cccc1F
HCID87438

2,6-Difluorobenzoyl chloride

C7H3ClF2O

结构：CC(C)(C)OC(=O)[C@@H](N)Cc1ccc(O)cc1
HCID6950582

L-Tyrosine 1,1-dimethylethyl ester

C13H19NO3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1c(F)cccc1F
HCID66843056

未命名化合物

PROCEDURE

实验过程

L-tyrosine tert-butyl ester (10.0 g) was acylated with 2,6-difluorobenzoyl chloride in a similar manner as described Example 1-(5) to give N-(2,6-difluorobenzoyl)-L-tyrosine tert-butyl ester (15.9 g). mp. 145-148° C.; IR (Nujol) 1728, 1638 cm−1; MS (APCI) m/z 395 (M+NH4), 378 (M+H).