反应详情

19.40 g (0.1 mole) of 2,4-dichloro-5-nitropyrimidine was completely dissolved in 60 ml of methanol and maintained below 15° C. To this solution, a solution of 12.22 g (0.2 mole) of ethanolamine in 20 ml of methanol was added slowly while maintaining the temperature of a reactor below 20° C. The mixture was stirred below 15° C. for 18 hours. After completion of the reaction, the reaction product was maintained below 5° C., and the resulting crystal was filtered, washed and dried, thereby giving 18.58 g (85% yield) of light yellow-colored 2-chloro-4-(2-hydroxyethylamino)-5-nitropyrimidine.

1. temperaturemaintained below 15° C
2. temperaturewhile maintaining the temperature of a reactor below 20° C
3. customAfter completion of the reaction
4. temperaturethe reaction product was maintained below 5° C.
5. filtrationthe resulting crystal was filtered
6. washwashed
7. customdried