反应详情

温度

55 °C

21.86 g (0.1 mole) of 2-chloro-4-(2-hydroxyethylamino)-5-nitropyrimidine was dissolved in 500 ml of ammonia saturated ethanol solution, and maintained between 50-60° C. A stream of ammonia was bubbled through the mixture for 13 hours. After completion of the reaction, the reaction product was maintained below 5° C., and the resulting crystal was filtered, washed and dried, thereby giving 18.81 g (93% yield) of light yellow-colored 2-amino-4-(2-hydroxyethylamino)-5-nitropyrimidine.

1. customA stream of ammonia was bubbled through the mixture for 13 hours
2. customAfter completion of the reaction
3. temperaturethe reaction product was maintained below 5° C.
4. filtrationthe resulting crystal was filtered
5. washwashed
6. customdried