反应详情

A mixture of (6-methoxy-benzofuran-3-yl)-acetic acid (2 g, 9.7 mmol) and H2SO4 (0.3 mL) in methanol (40 mL) was refluxed for 8 h and then concentrated. An aqueous NaHCO3 solution was added, followed by extraction with CH2Cl2. The combined organic layers were dried over anhydrous MgSO4 and evaporated to give a brown oil, which was purified on a silica gel column eluting with EtOAc/hexane (1:10) to give methyl 2-(6-methoxybenzofuran-3-yl)acetate (2.1 g, 98%)

1. temperaturewas refluxed for 8 h
2. concentrationconcentrated
3. additionAn aqueous NaHCO3 solution was added
4. extractionfollowed by extraction with CH2Cl2
5. dry with materialThe combined organic layers were dried over anhydrous MgSO4
6. customevaporated
7. customto give a brown oil, which
8. customwas purified on a silica gel column
9. washeluting with EtOAc/hexane (1:10)