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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 273341Generated: October 30, 2026

5-Bromo-1,2,3-trimethoxybenzene → (6-Methoxy-2-methyl-3a,7a-dihydro-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone

https://huagongshe.com/reaction/273341

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-1,2,3-trimethoxybenzeneHCID 75885—
Reactant6-Methoxy-2-methylbenzofuran-3-carbaldehydeHCID 86606188—
CatalystManganese dioxideHCID 14801—
Product(6-Methoxy-2-methyl-3a,7a-dihydro-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)-methanoneHCID 58668400—

Reaction Steps

6-Methoxy-2-methylbenzofuran-3-carbaldehyde was coupled with 3,4,5-trimethoxybromobenzene and subsequently oxidized by MnO2 in a manner similar to that described in Example 11 to afford compound 12.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07456289B2
Source datasetuspto-grants-2008_11
ORD IDord-946fa38e2692420cb8005b22fcf9196f
Source noteuspto-grants-2008_11