p-Toluenesulfonic acid monohydrate → HCID 57413460, compound

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A mixture of methyl 3-[4-[[2′,6′-dimethyl-4′-(tetrahydro-2H-pyran-2-yloxy)biphenyl-3-yl]methoxy]phenyl]propanoate (2.92 g, 6.15 mmol), p-toluenesulfonic acid monohydrate (0.12 g, 0.62 mmol) and methanol (60 mL) was stirred at room temperature for 2 hrs., and the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-hexane/ethyl acetate=1/2) to give the title compound (2.12 g, yield 88%) as a red oil.

Provenance & Evidence